Commercializing high technologies is expensive, tedious, and resource intensive. Meanwhile, there is a need for quick diffusion of innovations due to economic pressures for companies and research institutes. Therefore, this article proposes a new framework: lean commercialization. The framework represents a transformation of new technology and knowledge to products and services through the application of the lean/agile methodology. This methodology focuses on how resources can be minimized during the development, manufacturing, and marketing of new products and services, while still being accepted by customers. The lean commercialization framework was developed from a case study of high-technology companies and by interviewing commercialization experts. This article contributes to the theory and practice of commercialization of high technologies and provides a procedure for the practical application of the lean commercialization framework.